Effects of 2-acetylaminofluorene on transfer RNA methyltransferases of rat organs.
نویسندگان
چکیده
1922 Isolation and Characterization of a Cytosol Protein 1990 (64/7.2) Present in Large Amounts in Rapidly Grow ing Hepatomas. Katari S. Raju, Ann Cartwright, Friedrich W. Hirsch, Benjamin C. Wu, Katrina N. Nail, Harold P. Morris, and Harris Busch. Interactions between Polonium-210 «-Radiation, Benzo(a)pyrene, and 0.9% NaCI Solution Instilla tions in the Induction of Experimental Lung Cancer. John B. Little, Robert B. McGandy, and Ann R. Kennedy.
منابع مشابه
Effects of carcinogens and other agents on histone methylation by a histone arginine methyltransferase purified from rat liver cytoplasm.
S-Adenosyl-i.-ethionine has been found to inhibit histone methylation by an arginine methyltransferase purified from rat liver cytoplasm, in the presence of S-adenosyl-i -methionine. The enzyme is able to transfer alkyl groups from either of the activated amino acids to histone and with comparable efficiency. Histone methylation is also inhibited by /V-hydroxy-2-acetylaminofluorene (40% at 1 mv...
متن کاملOn the significance and mechanism of the binding of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene to rat-liver ribonucleic acid in vivo.
Previous reports that radioactivity was bound to liver RNA after administration of 2-acetylaminofluorene-9-14C or N-hydroxy-2-acetylaminofluorene-9-14C in species susceptible to the carcinogenic action of 2-acetylaminofluorene have been con firmed. Injection of l-hydroxy-2-acetylaminofluorene-l-14C, a noncarcinogenic metabolite of 2-acetylaminofluorene, did not result in any binding of radioact...
متن کاملPersistent binding of 2-acetylaminofluorene to rat liver DNA in vivo and consideration of the mechanism of binding of N-hydroxy-2-acetylaminofluorene to rat liver nucleic acids.
Previous reports that radioactivity was bound to rat liver DNA in vivo after administration of 2-acetylaminofluorene (AAF)-9-14C were confirmed. In addition, administration of several other AAF derivatives, namely N-hydroxy-AAF-9 -14C, N-acetoxy-AAF-914C, and the glucuronide of N-hydroxyAAF-9)4C, led to the binding of higher levels of radioactivity to rat liver ribosomal RNA and DNA. Maximum le...
متن کاملEffect of glutathione depletion on the hepatotoxicity and covalent binding rat liver macromolecules of N-hydroxy-2-acetylaminofluorene.
Glutathione plays an important role in the protection of the liver against several hepatotoxins. The hepatocarcinogen N-hydroxy-2-acetylaminofluorene is converted in the rat in vivo to reactive metabolites that bind covalently to cellular macromolecules. These metabolites may also react with glutathione, resulting in the formation of glutathione conjugates and in the detoxification of reactive ...
متن کاملThe effects of 2-acetylaminofluorene on the embryonic development of the zebrafish. II. Histochemical studies.
Although some studies have been made on the effects of carcinogens on the embryonic develop ment of various animals (1, 5, 9, 15, 17, 18, 22), little effort has been expended in studying the mode of action of these chemical compounds. A previous paper (11) described the teratogenic ef fects of 2-acetylaminofluorene (AAF) on the de velopment of the zebrafish; the abnormalities in cluded a distor...
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ورودعنوان ژورنال:
- Cancer research
دوره 38 7 شماره
صفحات -
تاریخ انتشار 1978